Single-Particle Cryo-EM
High-resolution structure determination of purified proteins and macromolecular complexes. Our facilities offer access to state-of-the-art Titan Krios microscopes capable of achieving near-atomic resolution.
- Sub-2 Angstrom resolution capability
- Automated data collection
- Support for challenging samples
Cryo-Electron Tomography
Study molecular structures in their native cellular context. Cryo-ET enables visualization of unique structures within cells and tissues at nanometer resolution.
- In-situ structural biology
- Cellular architecture analysis
- Cryo-FIB milling for thin lamella preparation
Sample Preparation
Comprehensive sample preparation services including grid optimization, vitrification, and screening to ensure high-quality data collection.
- Grid type optimization
- Vitrification parameter screening
- Negative stain pre-screening
Data Processing
Expert support for cryo-EM data processing, from motion correction to final structure refinement using industry-standard software packages.
- High-performance computing clusters
- RELION, cryoSPARC, and other packages
- Model building and refinement support
Screening & Assessment
Rapid sample quality assessment using screening microscopes to optimize samples before committing to high-end data collection.
- Quick turnaround times
- Sample optimization feedback
- Grid quality assessment
Training & Education
Hands-on training courses and workshops for researchers new to cryo-EM, covering sample preparation, data collection, and image processing.
- Beginner to advanced courses
- Practical hands-on sessions
- One-on-one guidance